Substance Structure:
Modified molecular structure combining transport features with a designed N-(docosahexaenoyl)-glycylaminomethylisoxazole architecture.
Mechanism of Action:
Dual BBB vector: passive diffusion via the hydrophobic DHA acyl tail and active uptake by LAT1 transporters via the glycine spacer.
Bioeffect and Properties:
Concept of pre-receptor system readiness to bypass cortisol-induced receptor desensitization and release of the active components within the CNS.
Status and Archive:
Archived at Phase 2 due to synthetic technological complexity, risks of acid degradation of the isoxazole ring, and low yield (failure to meet cost-effectiveness criteria).
Technological Tools:
Multi-stage modular synthesis, covalent conjugation of structural fragments, assessment of pure substance commercial yield.
DHA-Gly-Msc
LIPID-TRANSPORT TRIPLE CONJUGATE